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Dr. Hagop Kantarjian Receives the 18th Annual AACR Joseph H. Burchenal Memorial Award
Cisplatin-resistant Cancer Cells Sensitive to Experimental Anticancer Drugs Called PARP Inhibitors
Obesity, Physical Inactivity Linked With Risk for Certain Molecular Subtype of Colorectal Cancer
MicroRNA Molecule May Serve as Biomarker, Target for Brain Metastases in Breast Cancer Patients
Common Genetic Alteration Found in Head and Neck Cancers May Not be Key to Effective Treatment

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Dr. Hagop Kantarjian Receives the 18th Annual AACR Joseph H. Burchenal Memorial Award

WASHINGTON, D.C. — Hagop M. Kantarjian, M.D., will receive the 18th Annual AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research at the American Association for Cancer Research Annual Meeting 2013, held in Washington...

Published Sat, Apr 04 2013 6:15 PM by AACR News

Filed under: Press Releases, Media Materials, AACR, American Association for Cancer Research, Cancer Research, leukemia, 2013 Annual Meeting, Dr. Hagop Kantarjian, BCR-ABL protein, AACR Joseph H. Burchenal Memorial Award, acute lymphoid leukemia
Cisplatin-resistant Cancer Cells Sensitive to Experimental Anticancer Drugs Called PARP Inhibitors

Cisplatin-resistant non-small cell lung cancer cells expressed high levels of hyperactivated PARP1. Cells succumbed to PARP inhibitors in vitro. PARP inhibitor slowed cisplatin-resistant tumor growth in mice. PHILADELPHIA — Poly (ADP-ribose) polymerase...

Published Wed, Apr 04 2013 12:05 AM by AACR News

Filed under: Press Releases, Research, Treatment, Cancer, Media Materials, AACR, lung cancer, American Association for Cancer Research, Cancer Research, journal, non-small cell lung cancer, NSCLC, cisplatin, PARP1, PARP inhibitor, cisplatin resistance, PAR, Dr. Guido Kroemer
Obesity, Physical Inactivity Linked With Risk for Certain Molecular Subtype of Colorectal Cancer

Obesity increased risk; physical activity lowered risk. Data consistent with prior research linking exercise to decreased mortality. Research on colon cancer should incorporate heterogeneity of disease. PHILADELPHIA — An increasing body mass index...

Published Tue, Feb 02 2013 1:00 PM by AACR News

Filed under: Press Releases, Research, Obesity, exercise, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, colorectal cancer, journal, risk, BMI, Physical activity, CTNNB1, Dr. Shuji Ogino
MicroRNA Molecule May Serve as Biomarker, Target for Brain Metastases in Breast Cancer Patients

MicroRNA molecule called miR-7 decreased in highly metastatic cancer stem-like cells. miR-7 attenuated cancer stem-like cells’ capacity for brain metastasis in mice. MicroRNA molecule suppressed KLF4 expression. PHILADELPHIA — Researchers...

Published Tue, Feb 02 2013 1:00 PM by AACR News

Filed under: Press Releases, Research, Breast Cancer, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, journal, microRNA, biomarker, brain metastasis, therapeutic target, Dr. Kounosuke Watabe
Common Genetic Alteration Found in Head and Neck Cancers May Not be Key to Effective Treatment

Common pathway activation may not be “driving” tumor. Deregulation of several genetic pathways may explain treatment resistance. PHILADELPHIA — Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR...

Published Tue, Jan 01 2013 1:00 PM by AACR News

Filed under: Press Releases, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, genetics, Cancer Research, journal, head and neck cancer, PI3K/AKT/mTOR pathway, rapamycin, mTOR inhibitors, AKT inhibitor, Dr. Pradip K. Majumder
Treatment Targeting PI3K May Delay Resistance to Anti-HER2 Therapy in Breast Cancer Patients

Early use of PI3K inhibitors may prevent or delay treatment resistance. Cancer cells resistant to anti-HER2 therapy had high levels of survivin. Newly identified biomarker may help predict anti-HER2 therapy resistance. PHILADELPHIA — Patients with...

Published Wed, Jan 01 2013 9:00 AM by AACR News

Filed under: Press Releases, Research, Breast Cancer, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, women, journal, Trastuzumab, HER2-positive breast cancer, therapy resistance, PI3K, Dr. Carlos L. Arteaga
New Model May Help Predict Response to Chemotherapy for Colorectal Cancer

Mathematical model measures stress level needed to produce cell death. Model could eventually be applied in other cancers. PHILADELPHIA — Scientists may be able to better predict which patients with colorectal cancer will respond to chemotherapy...

Published Thu, Jan 01 2013 12:05 AM by AACR News

Filed under: Press Releases, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, chemotherapy, Cancer Research, colorectal cancer, journal, predict, model, DR_MOMP, MOMP, Dr. Jochen J.M. Prehn, mitochondrial outer membrane permeabilization, BCL-2
Obesity and Overeating During Menopause Together Promote Breast Tumor Growth and Progression

In a rat model, premenopausal obesity impaired ability to handle postmenopausal overeating. Obese animals’ tumors expressed more markers of increased energy use and proliferation. Results have implications for weight and metabolic control in perimenopausal...

Published Fri, Dec 12 2012 10:00 AM by AACR News

Filed under: Press Releases, Research, Breast Cancer, Obesity, Cancer, Media Materials, AACR, American Association for Cancer Research, prevention, Cancer Research, women, diet, journal, Metformin, weight, Dr. Paul S. MacLean, premenopause
Potential New Technique for Anticancer Radiotherapy Could Provide Alternative to Brachytherapy

New approach could be alternative to surgical implantation of radioactive “seeds.” Injected radioactive substance was retained in tumors in mice. Tumor growth was delayed in all treated animals. PHILADELPHIA — A promising new approach...

Published Thu, Nov 11 2012 12:05 AM by AACR News

Filed under: Press Releases, Research, Treatment, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, journal, radiotherapy, Brachytherapy, solid tumors, Dr. Wenge Liu
New Mechanism of Action for PARP Inhibitors Discovered

PARP inhibitors are promising treatments for BRCA-mutant breast and ovarian cancers. Researchers have identified a new way in which these drugs work. New genetic mutations rendering cells susceptible to PARP inhibitors are also identified. Patients with...

Published Fri, Nov 11 2012 11:21 AM by AACR News

Filed under: Press Releases, Research, Treatment, Breast Cancer, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, women, ovarian cancer, journal, genetic mutation, PARP inhibitors, BRCA-mutant, Dr. Yves Pommier
Obesity Promotes Tumor Growth Regardless of Diet

Presence of fat tissue-derived cells in tumors is related to increased tumor growth. The cells incorporate into the blood vessel network that supports tumor growth. Blocking recruitment of the cells could provide a new therapeutic approach. PHILADELPHIA...

Published Mon, Oct 10 2012 12:05 AM by AACR News

Filed under: Press Releases, Research, Obesity, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, diet, journal, white adipose tissue, Dr. Mikhail Kolonin
Noninvasive Measurement Enables Use of Interstitial Fluid Pressure as Potential Biomarker for Tumor Aggressiveness

Higher IFP linked with treatment resistance and metastasis. Identification of IFP could dictate appropriate use of aggressive therapies. Further assessment of noninvasive measurement needed. PHILADELPHIA — Researchers validated a method of noninvasive...

Published Mon, Oct 10 2012 12:05 AM by AACR News

Filed under: Press Releases, imaging, MRI, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, journal, biomarker, metastasis, noninvasive, IFP, interstitial fluid pressure, Dr. Einar K. Rofstad
Assessment of HPV DNA Alone Insufficient to Identify HPV-driven Head and Neck Cancers

Viral load and cancer-specific gene expression identified as potential markers. Head-to-head biomarker comparison is crucial. PHILADELPHIA — Human papillomavirus (HPV) DNA positivity alone, particularly when assessed using polymerase chain reaction...

Published Tue, Sep 09 2012 1:00 PM by AACR News

Filed under: Press Releases, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, Diagnosis, human papillomavirus, biomarkers, HPV, head and neck cancer, Dr. Dana Holzinger, oropharyngeal cancer, Dr. Karl T. Kelsey
PARP Inhibitors May Have Clinical Utility in HER2-positive Breast Cancers

PARP inhibitors are promising treatments for BRCA-associated familial breast and ovarian cancers. They may have activity outside of familial cancers independent of DNA repair defects. PHILADELPHIA — Poly (ADP-Ribose) polymerase (PARP) inhibitors...

Published Mon, Sep 09 2012 12:05 AM by AACR News

Filed under: Press Releases, Research, Treatment, Breast Cancer, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, women, BRCA, HER2, PARP inhibitor, Dr. Eddy S. Yang
Mechanisms of Acquired Chemoresistance in Ovarian Cancer Identified

Disease has high heterogeneity. First-line chemosensitivity associated with subsequent chemoresistance. Gene identified that may predict chemoresistance. PHILADELPHIA — The presence of multiple ovarian cancer genomes in an individual patient and...

Published Wed, Aug 08 2012 12:05 AM by AACR News

Filed under: Press Releases, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, chemotherapy, Cancer Research, women, ovarian cancer, journal, gene, chemoresistance, LRP1B, Dr. David Bowtell

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