Patients with lung cancer and KRAS mutation responded well to antifolate therapy. Response linked to downregulation of KRAS expression. Downregulation may render cells more susceptible to chemotherapeutic drug. CHICAGO — Testing patients with non-small cell lung cancer for both mutations and amplifications...
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Wed, Apr 4 2012
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Filed under: Press Releases, Research, Cancer, Media Materials, AACR, lung cancer, American Association for Cancer Research, meeting, KRAS, non-small cell lung cancer, pemetrexed, Dr. Sarah Bacus, 2012 Annual Meeting, Annual Meeting, AACR Annual Meeting 2012, antifolate
Aggressive lung cancers harboring KRAS mutations are sensitive to antifolates. Antifolates decrease KRAS gene expression. Large clinical trials needed to investigate antifolate effects in cancers with respect to driving mutations. SAN FRANCISCO — Patients with non-small cell lung cancer who have...
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Sun, Nov 13 2011
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Filed under: Press Releases, Research, Treatment, Conference, Cancer, Media Materials, AACR, lung cancer, American Association for Cancer Research, mutations, meeting, National Cancer Institute, NCI, KRAS, non-small cell lung cancer, Molecular Targets, AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Cancer Therapeutics, EORTC, European Organisation for Research and Treatment of Cancer, pemetrexed, antifolates, methotrexate, Dr. Sarah Bacus