MYCN gene is commonly amplified in neuroblastoma and associated with poor prognosis. A BET bromodomain inhibitor downregulated MYCN expression. The drug prolonged survival in three animal models of MYCN-amplified neuroblastoma. PHILADELPHIA — Neuroblastoma, the most common malignant tumor of early...
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Thu, Feb 21 2013
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Filed under: Press Releases, Research, Treatment, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Discovery, Stand Up To Cancer, SU2C, journal, Pediatric cancer, childhood cancer, neuroblastoma, biomarker, MYCN, Dr. Kimberly Stegmaier, BET bromodomain inhibitors
MicroRNA molecule called miR-7 decreased in highly metastatic cancer stem-like cells. miR-7 attenuated cancer stem-like cells’ capacity for brain metastasis in mice. MicroRNA molecule suppressed KLF4 expression. PHILADELPHIA — Researchers have identified two molecules that could potentially...
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Tue, Feb 5 2013
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Filed under: Press Releases, Research, Breast Cancer, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, journal, microRNA, biomarker, brain metastasis, therapeutic target, Dr. Kounosuke Watabe
Higher IFP linked with treatment resistance and metastasis. Identification of IFP could dictate appropriate use of aggressive therapies. Further assessment of noninvasive measurement needed. PHILADELPHIA — Researchers validated a method of noninvasive imaging that provides valuable information...
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Mon, Oct 1 2012
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Filed under: Press Releases, imaging, MRI, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, Cancer Research, journal, biomarker, metastasis, noninvasive, IFP, interstitial fluid pressure, Dr. Einar K. Rofstad
Pazopanib achieved the primary endpoint of response. Interleukin-8 may be an indicator of tumor resistance and poor survival. Data need further validation in a large patient population. CHICAGO — The antiangiogenic drug pazopanib has demonstrated clinically meaningful activity in patients with...
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Sat, Mar 31 2012
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Filed under: Press Releases, Research, Cancer, Media Materials, AACR, American Association for Cancer Research, meeting, biomarker, 2012 Annual Meeting, Annual Meeting, AACR Annual Meeting 2012, Andrea Necchi, refractory urothelial cancer
Reductions of markers like PGE2 may be a biomarker for colon cancer prevention. Phase II study conducted in humans requires validation. Natural supplement use could be potential cancer prevention strategy. PHILADELPHIA — Ginger supplements reduced markers of colon inflammation in a select group of patients...
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Tue, Oct 11 2011
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Filed under: Press Releases, Research, inflammation, Media Materials, AACR, cancer prevention, American Association for Cancer Research, prevention, Cancer Prevention Research, National Cancer Institute, NCI, colon cancer, supplement, biomarker, ginger, naturopathic doctor, University of Michigan Medical School, ginger root, Dr. Suzanna M. Zick, PGE2, natural supplement